Prof. Zheng Huang Profile

Prof. Zheng Huang

Professor at Fujian Normal Univ

SPIE Involvement:

Author

Area of Expertise:

Photodynamic Therapy , Sonodynamic Therapy , Laser Medicine , Biomedical Optics , Biophotonics , Biomedical Engineering

Publications (57)

Proceedings Article | 27 November 2023 Poster + Paper

In vivo study of photodynamic effect induced by combination of IPL and HMME

Weijin Peng, Xingran Guo, Huiqi Zhan, Cheng Ke, Xin Wang, Zheng Huang

Proceedings Volume 12770, 127702Y (2023) https://doi.org/10.1117/12.2687527

KEYWORDS: Skin, Ear, Photodynamic therapy, Animal model studies, In vivo imaging, Light sources, Tissues, Phototherapy

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Proceedings Article | 27 November 2023 Poster + Paper

Feasibility study of quantifying size of port-wine stain (PWS) birthmarks using digital photos

Cheng Ke, Huiqi Zhan, Chunfa Wu, Zheng Huang, Yuanbo Huang, Jun Yang, Mingye Bi

Proceedings Volume 12770, 127702U (2023) https://doi.org/10.1117/12.2687490

KEYWORDS: Cameras, RGB color model, Photography, Color, Image processing, Skin

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Proceedings Article | 27 November 2023 Poster + Paper

Optimizing single photon detection based on superconducting strip photon detector (SSPD) for singlet oxygen luminescence detection

Shengdong Cui, Cheng Ke, Weijin Peng, Xianzeng Zhang, Zheng Huang, Lixing You

Proceedings Volume 12770, 127702S (2023) https://doi.org/10.1117/12.2687455

KEYWORDS: Oxygen, Photodetectors, Luminescence, Superconductors, Polarization, Signal detection, Signal attenuation, Pulse signals, Photon polarization, Photodynamic therapy

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Proceedings Article | 19 December 2022 Presentation + Paper

Evaluation of deep learning approaches for dermoscopic evaluation of vascular features of port-wine stain birthmarks

Sen Wang, Cheng Ke, Shengdong Cui, Chunfa Wu, Zheng Huang, Yuanbo Huang, Jun Yang, Lichao Zhang, Mingye Bi

Proceedings Volume 12320, 123200G (2022) https://doi.org/10.1117/12.2643849

KEYWORDS: Data modeling, Image classification, Image processing, Medical imaging, Image analysis

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Proceedings Article | 19 December 2022 Presentation + Paper

Preliminary study on photodynamic effect of intense pulsed light (IPL) excitation of porphyrin photosensitizer

Xin Wang, Zheng Zou, Weijin Peng, Cheng Ke, Zheng Huang, Min Li

Proceedings Volume 12320, 1232015 (2022) https://doi.org/10.1117/12.2643727

KEYWORDS: Photodynamic therapy, Light sources, Absorption, Photosensitizer targeting, In vitro testing

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Proceedings Article | 9 October 2021 Poster + Paper

In vitro study of YLG-1 mediated photodynamic effect on human cancer cells

Na Meng, Xin Wang, Jie Jiang, Rui Ding, Zhen Han, Zheng Huang

Proceedings Volume 11900, 119001R (2021) https://doi.org/10.1117/12.2600758

KEYWORDS: Photodynamic therapy, Cancer, In vitro testing, Ovarian cancer, Semiconductor lasers

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Proceedings Article | 9 October 2021 Presentation + Paper

Comparison of different light sources for hemoporfin mediated photodynamic activity

Na Meng, Sen Wang, Shuling Zou, Min Li, Min Wang, Zheng Huang

Proceedings Volume 11900, 119000Z (2021) https://doi.org/10.1117/12.2600765

KEYWORDS: Light sources, Light emitting diodes, Photodynamic therapy, Absorption, Semiconductor lasers, Green light emitting diodes, Light

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Proceedings Article | 9 October 2021 Poster + Paper

Uniformity evaluation of renal tubular distribution in the ischemia-reperfusion process based on fractal theory

Yuhong Fang, Wei Gong, Zheng Huang, Shusen Xie

Proceedings Volume 11900, 119001N (2021) https://doi.org/10.1117/12.2600622

KEYWORDS: Fractal analysis, Kidney, Optical coherence tomography, Ischemia, Injuries, In vivo imaging, Particles, Image processing, Blood, 3D image processing

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Proceedings Article | 9 October 2021 Presentation + Paper

Preliminary study of surface-enhanced Raman spectroscopy (SERS) of serum samples of liver cancer patients

Qiwen Wang, Mengmeng Zheng, Yuhong Fang, Kecan Lin, Shusen Xie, Zheng Huang

Proceedings Volume 11900, 119000U (2021) https://doi.org/10.1117/12.2602627

KEYWORDS: Liver cancer, Surface enhanced Raman spectroscopy, Blood, Cancer, Silver, Raman spectroscopy, Proteins, Molecules, Liver

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Proceedings Article | 10 October 2020 Poster + Paper

Variation of optical attenuation coefficient during ischemia-reperfusion process of rabbit kidney measured by optical coherence tomography

Yuhong Fang, Wei Gong, Zheng Huang, Tao Li, Xiang Wu, Qingjiang Xu, Deyuan Yang, Shusen Xie

Proceedings Volume 11553, 115532R (2020) https://doi.org/10.1117/12.2575207

KEYWORDS: Optical coherence tomography, Kidney, Tissue optics, Signal attenuation, Optical testing, Ischemia, Injuries, Optical properties, Tissues, Blood

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Proceedings Article | 10 October 2020 Presentation + Paper

Quantitative detection of protoporphyrin IX (PpIX) fluorescence in tissues

Jian Zou, Na Meng, Weijun Li, Shusen Xie, Chunfa Wu, Zheng Huang

Proceedings Volume 11553, 115530V (2020) https://doi.org/10.1117/12.2575223

KEYWORDS: Luminescence, Tissues, Fluorescence spectroscopy, Calibration, Photodynamic therapy, Absorption, Scattering, Monte Carlo methods, Light scattering, Detector development

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Proceedings Article | 10 October 2020 Poster + Paper

Evaluation of different denoising algorithms for OCT image denoising

Weijun Li, Jian Zou, Na Meng, Yuhong Fang, Zheng Huang

Proceedings Volume 11553, 115532T (2020) https://doi.org/10.1117/12.2575240

KEYWORDS: Optical coherence tomography, Denoising, Image denoising, Gaussian filters, Image quality, Image filtering, Signal to noise ratio, Digital filtering, Signal processing, Tissues

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Proceedings Article | 20 November 2019 Paper

Research on ischemia-reperfusion injury of rat kidney using optical coherence tomography

Yuhong Fang, Wei Gong, Zheng Huang, Liqin Zheng, Hongxin Lin, Deyuan Yang, Shusen Xie

Proceedings Volume 11190, 1119032 (2019) https://doi.org/10.1117/12.2537737

KEYWORDS: Kidney, Optical coherence tomography, Injuries, Arteries, In vivo imaging, Ischemia, Renal calculi, Surgery, Transplantation, Image resolution

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Proceedings Article | 20 November 2019 Paper

Preliminary study of sonodynamic effects of a novel water soluble chlorin

Jiang Jie, Jian Zou, Rui Ding, Zhen Han, Weijun Li, Zheng Huang

Proceedings Volume 11190, 1119016 (2019) https://doi.org/10.1117/12.2537785

KEYWORDS: Luminescence, Ultrasonography, Raman spectroscopy, Oxygen, Absorption, Spectroscopy, Photodynamic therapy, Fluorescence spectroscopy, Ultrasonics, Transducers

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Proceedings Article | 22 July 2019 Paper

Quantitative analysis of portwine stainbirthmark color in PDT treatment

Jie Jiang, Weijun Li, Yuzhi Wang, Kaihua Yuan, Kui Dong, Zheng Huang

Proceedings Volume 11079, 1107919 (2019) https://doi.org/10.1117/12.2526585

KEYWORDS: Photodynamic therapy, Digital photography, Skin, Photography, RGB color model, Quantitative analysis, Software development, Color difference, Light sources and illumination

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Proceedings Article | 22 July 2019 Paper

Evaluation of singlet oxygen production of a novel chlorin photosensitizer

Jian Zou, Jie Jiang, Zhen Han, Rui Ding, Zheng Huang

Proceedings Volume 11079, 110790L (2019) https://doi.org/10.1117/12.2526579

KEYWORDS: Luminescence, Photodynamic therapy, Quantum efficiency, Sensors, Optical properties, Absorbance

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Proceedings Article | 19 July 2019 Paper

Evaluation of optical attenuation coefficient of living kidney using OCT

Weijun Li, Chunfa Wu, Yuhong Fang, Junxia Li, Zheng Huang

Proceedings Volume 11078, 1107828 (2019) https://doi.org/10.1117/12.2526592

KEYWORDS: Optical coherence tomography, Kidney, Signal attenuation, Tissues, Ischemia, Optical properties, Light scattering

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Proceedings Article | 5 November 2018 Paper

Optical coherence tomography (OCT) examination of living kidney – animal study

Weijun Li, Yuhong Fang, Junxia Li, Wei Gong, Yongzeng Li, Shushen Xie, Zheng Huang

Proceedings Volume 10816, 108160J (2018) https://doi.org/10.1117/12.2502718

KEYWORDS: Optical coherence tomography, Kidney, 3D image processing, Tissues, Binary data

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Proceedings Article | 5 November 2018 Paper

OCT of living human kidney: case study

Yuhong Fang, Wei Gong, Junxia Li, Jianming Tan, Weijun Li, Yongzeng Li, Shusen Xie, Zheng Huang

Proceedings Volume 10816, 108161R (2018) https://doi.org/10.1117/12.2502655

KEYWORDS: Optical coherence tomography, Kidney, Image segmentation, 3D image processing, Transplantation, Image analysis, Distortion

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Proceedings Article | 23 October 2018 Paper

Evaluation of singlet oxygen luminescence of a novel chlorin photosensitizer

Jian Zou, Jie Jiang, Zhen Han, Lisheng Lin, Yongzhen Li, Zheng Huang

Proceedings Volume 10820, 108203C (2018) https://doi.org/10.1117/12.2502481

KEYWORDS: Oxygen, Luminescence, Absorption, Photodynamic therapy, Quantum efficiency, Absorbance, Light sources, Spectroscopy

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Proceedings Article | 12 February 2018 Presentation + Paper

Reactive oxygen species explicit dosimetry (ROSED) of a type 1 photosensitizer

Yi Hong Ong, Michele Kim, Zheng Huang, Timothy Zhu

Proceedings Volume 10476, 104760V (2018) https://doi.org/10.1117/12.2291385

KEYWORDS: Photodynamic therapy, Tumors, Oxygen, Tissues, Tissue optics, Blood circulation, Optical properties

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Proceedings Article | 1 August 2017 Paper

Preliminary evaluation of a water soluble chlorin photosensitizer

Jian Zou, Qiuyan Huang, Weijun Li, Shulin Zou, Zhen Han, Zheng Huang

Proceedings Volume 10417, 104170E (2017) https://doi.org/10.1117/12.2291936

KEYWORDS: Photodynamic therapy, Absorption, Fluorescence spectroscopy

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Proceedings Article | 9 March 2015 Paper

Treating cutaneous squamous cell carcinoma using ALA PLGA nanoparticle-mediated photodynamic therapy in a mouse model

Xiaojie Wang, Lei Shi, Qingfeng Tu, Hongwei Wang, Haiyan Zhang, Peiru Wang, Linglin Zhang, Zheng Huang, Xiuli Wang, Feng Zhao, Hansen Luan

Proceedings Volume 9324, 93240U (2015) https://doi.org/10.1117/12.2077939

KEYWORDS: Photodynamic therapy, Tumors, Luminescence, Skin, Nanoparticles, Mouse models, Tissues, Tissue optics, Ultraviolet radiation, Skin cancer

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Proceedings Article | 2 March 2015 Paper

Block copolymers encapsulated poly (aryl benzyl ether) dendrimer silicon (IV) phthalocyanine for in vivo and in vitro photodynamic efficacy of choroidal neovascularization

Xiongwei Wang, Kuizhi Chen, Zheng Huang, Yiru Peng

Proceedings Volume 9308, 93080L (2015) https://doi.org/10.1117/12.2081532

KEYWORDS: Dendrimers, Silicon, Nanoparticles, In vivo imaging, In vitro testing, Photodynamic therapy, Luminescence, Spectrometers, Semiconductor lasers, Laser applications

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Proceedings Article | 2 March 2015 Paper

Photoinduced electron transfer between the dendritic zinc phthalocyanines and anthraquinone

Kuizhi Chen, Junri Wen, Jiangsheng Liu, Zhenzhen Chen, Sujuan Pan, Zheng Huang, Yiru Peng

Proceedings Volume 9308, 93080U (2015) https://doi.org/10.1117/12.2078428

KEYWORDS: Luminescence, Zinc, Dendrimers, Energy transfer, Polymers, Absorption, Absorption spectroscopy, Fluorescence spectroscopy, Spectroscopy, Solar energy

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Proceedings Article | 17 September 2014 Paper

Optical coherence tomography examination of hair

Wei Gong, Zheng Huang, Jianshu Xu, Hongqin Yang, Hui Li, Shusen Xie

Proceedings Volume 9230, 923013 (2014) https://doi.org/10.1117/12.2069237

KEYWORDS: Optical coherence tomography, Visualization, Tissue optics, Structured optical fibers, Imaging systems, Skin, Tissues, Image resolution, In vivo imaging, Optoelectronics

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Proceedings Article | 17 September 2014 Paper

In vivo study of ALA PLGA nanoparticles-mediated PDT for treating cutaneous squamous cell carcinoma

Xiaojie Wang, Lei Shi, Zheng Huang, Xiuli Wang

Proceedings Volume 9230, 92301D (2014) https://doi.org/10.1117/12.2069455

KEYWORDS: Photodynamic therapy, Tumors, Skin, In vivo imaging, Mouse models, Skin cancer, Nanoparticles, Picosecond phenomena, Tissues, Ultraviolet radiation

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Proceedings Article | 19 March 2013 Paper

Characterizing autofluorescence generated from endogenous porphyrins in cancerous tissue of human colon: case studies

Lina Liu, Lisheng Lin, Weihua Li, Changshun Yang, Zheng Huang, Shusen Xie, Buhong Li

Proceedings Volume 8577, 857703 (2013) https://doi.org/10.1117/12.2002224

KEYWORDS: Tissues, Luminescence, Colon, Cancer, Colorectal cancer, Atrial fibrillation, Time resolved spectroscopy, Spectroscopy, Tissue optics, Fluorescence spectroscopy

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Proceedings Article | 25 February 2013 Paper

Topical photodynamic therapy of squamous cell carcinomas in a hairless mouse model

Hong-Wei Wang, Ting Lv, Jing-Jing Li, Qingfeng Tu, Zheng Huang, Xiu-Li Wang

Proceedings Volume 8582, 858204 (2013) https://doi.org/10.1117/12.2006297

KEYWORDS: Photodynamic therapy, Skin, Luminescence, Tumors, Skin cancer, Mouse models, Cell death, Ultraviolet radiation, Therapeutics, In vivo imaging

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Proceedings Article | 11 December 2012 Paper

Advanced optical techniques for monitoring dosimetric parameters in photodynamic therapy

Buhong Li, Zhihai Qiu, Zheng Huang

Proceedings Volume 8553, 85530F (2012) https://doi.org/10.1117/12.2001727

KEYWORDS: Photodynamic therapy, Tissue optics, Oxygen, Picosecond phenomena, Luminescence, Tissues, Diffuse reflectance spectroscopy, Doppler tomography, Optical properties, Blood circulation

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Proceedings Article | 3 March 2010 Paper

Preliminary study of optical properties of hematoporphyrin monomethyl ether (HMME), a new PDT sensitizer

Gregory Glazner, Tim Lei, Larry Scherrer, Srinivas Pendyala, Michael Duffy, Xiuli Wang, Hongwei Wang, Fred Hetzel, Zheng Huang

Proceedings Volume 7551, 75510P (2010) https://doi.org/10.1117/12.841080

KEYWORDS: Absorption, Luminescence, Photodynamic therapy, Oxygen, Optical properties, Quantum efficiency, Absorbance, Spectrophotometry, Clinical trials, Molecules

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Proceedings Article | 13 July 2009 Paper

Preliminary study of verteporfin photodynamic therapy in a canine prostate model

Zheng Huang, Fred Hetzel, Ken Dole, David Luck, Jill Beckers, Don Maul

Proceedings Volume 7380, 73801Y (2009) https://doi.org/10.1117/12.822930

KEYWORDS: Photodynamic therapy, Prostate, Bladder, Tissues, Colon, Prostate cancer, Tumors, Cancer, Animal model studies, Surgery

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Proceedings Article | 13 July 2009 Paper

Topical application of ALA PDT for the treatment of moderate to severe acne vulgaris

Xiu-Li Wang, Hong-Wei Wang, Ling-Lin Zhang, Lina Su, Ming-Xia Guo, Zheng Huang

Proceedings Volume 7380, 73801Z (2009) https://doi.org/10.1117/12.822700

KEYWORDS: Photodynamic therapy, Luminescence, Semiconductor lasers, Patents, Tissues, Skin, Light sources, Lamps, Oxygen, Laser therapeutics

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Proceedings Article | 13 July 2009 Paper

Combination of PDT and topical angiogenic inhibitor for treatment of port wine stain (PWS) birthmarks: a novel approach

Kaihua Yuan, Qiaobing Huang, Zheng Huang

Proceedings Volume 7380, 73802V (2009) https://doi.org/10.1117/12.823280

KEYWORDS: Photodynamic therapy, Blood vessels, Skin, Wound healing, Laser therapeutics, Dye lasers, Visualization, Pulsed laser operation, Absorption, Oxygen

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Proceedings Article | 25 February 2009 Paper

Preliminary study of cytotoxic effects of photodynamic therapy and immunotherapy on human pancreatic cancer cells

Luowei Wang, Bolin Liu, Yang Chen, Zhaoshen Li, Fred Hetzel, Zheng Huang

Proceedings Volume 7178, 71780C (2009) https://doi.org/10.1117/12.811904

KEYWORDS: Photodynamic therapy, Pancreatic cancer, Cell death, Proteins, Cancer, Receptors, Monoclonal antibodies, In vitro testing, In vivo imaging, Auroras

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Proceedings Article | 25 February 2008 Paper

Preliminary study of transurethral photodynamic therapy mediated with Tookad in a canine prostate model

Zheng Huang, Fred Hetzel, Qun Chen, Kenneth Dole

Proceedings Volume 6845, 68450J (2008) https://doi.org/10.1117/12.760741

KEYWORDS: Photodynamic therapy, Prostate, Tissues, Diffusers, Prostate cancer, Surgery, Tumor growth modeling, Visualization, Animal model studies, Bladder

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Proceedings Article | 18 February 2008 Paper

Combination of photodynamic therapy and immunotherapy - evolving role in dermatology

Xiu-Li Wang, Hong-Wei Wang, Zheng Huang

Proceedings Volume 6857, 685704 (2008) https://doi.org/10.1117/12.760769

KEYWORDS: Photodynamic therapy, Skin, Tumors, Cancer, Skin cancer, Dermatology, Oncology, Melanoma, Control systems, Colorectal cancer

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Proceedings Article | 18 January 2008 Paper

Determination of the optical properties of vascular tissues: potential applications in vascular-targeting photodynamic therapy

Yongbin Tian, Ping Chen, Lie Lin, Zheng Huang, Guoqing Tang, Heping Xu

Proceedings Volume 6826, 68261Q (2008) https://doi.org/10.1117/12.758255

KEYWORDS: Tissues, Photodynamic therapy, Optical properties, Monte Carlo methods, Absorption, Scattering, Light scattering, Modulation, Sensors, Phase measurement

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Proceedings Article | 18 January 2008 Paper

mTHPC-photodynamic therapy induced apoptosis in nasopharyngeal carcinoma cells

Christine Yow, Albert Leung, Zheng Huang

Proceedings Volume 6826, 68261P (2008) https://doi.org/10.1117/12.756807

KEYWORDS: Photodynamic therapy, Cell death, Proteins, Microscopy, Cancer, Microscopes, Luminescence, Sodium, Synthetic aperture radar, Modulation

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Proceedings Article | 27 February 2007 Paper

Effect of implanted brachytherapy seeds on optical fluence distribution: preliminary ex vivo study

Fred Hetzel, Qun Chen, Meisong Ding, Francis Newman, Kenneth Dole, Zheng Huang, Dominique Blanc

Proceedings Volume 6427, 64270J (2007) https://doi.org/10.1117/12.700756

KEYWORDS: Photodynamic therapy, Prostate, Sensors, Prostate cancer, Tissue optics, Diffusers, Light sources, Radio optics, X-rays, Light scattering

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Proceedings Article | 13 February 2007 Paper

Sonodynamic cytotoxic effect of hematoporphyrin monomethyl ether on C6 glioma cells - in vitro study

Wu Yue, Da-yong Song, Zhao Zhao, Shao-dong Cao, Xiang-xi Meng, Xu Zhang, Zheng Huang

Proceedings Volume 6438, 64380I (2007) https://doi.org/10.1117/12.703200

KEYWORDS: Ultrasonography, In vitro testing, Cell death, Transducers, Flow cytometry, Photodynamic therapy, Tumors, Cancer, Radiation oncology, Health sciences

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Proceedings Article | 13 February 2007 Paper

Imiquimod immunotherapy and ALA photodynamic therapy combination for the treatment of genital bowenoid papulosis

Xiu-Li Wang, Hong-Wei Wang, Ming-Xia Guo, Zheng Huang

Proceedings Volume 6438, 643809 (2007) https://doi.org/10.1117/12.698774

KEYWORDS: Gas lasers, Carbon monoxide, Photodynamic therapy, Laser therapeutics, Combustion, Skin cancer, Tissues, Skin, Cancer, Health sciences

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Proceedings Article | 13 February 2007 Paper

Clinical pharmacokinetics of protoporphyrin IX (PpIX) in condylomata acuminata patients: ex vivo fluorescence examination

Xiu-Li Wang, Hong-Wei Wang, Zheng Huang, Herbert Stepp, Reinhold Baumgartner, Christian Dannecker, Peter Hillemanns

Proceedings Volume 6438, 64380A (2007) https://doi.org/10.1117/12.705732

KEYWORDS: Luminescence, Biopsy, Fluorescence spectroscopy, Tissues, Skin, Photodynamic therapy, Microscopes, Biological research, Image analysis, Image filtering

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Proceedings Article | 21 July 2006 Paper

Effects of surgery, immunization, and laser immunotherapy on a non-immunogenic metastic tumor model

Wei Chen, Zheng Huang, Kirill Andrienko, Stefan Stefanov, Roman Wolf, Hong Liu

Proceedings Volume 6163, 61630F (2006) https://doi.org/10.1117/12.696957

KEYWORDS: Tumors, Laser therapeutics, Surgery, Therapeutics, Cancer, Laser vision correction, Tissues, Oncology, Control systems, Photomicroscopy

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Proceedings Article | 6 March 2006 Paper

Evaluation of Tookad-mediated photodynamic effect on peripheral nerve in a canine model

Fred Hetzel, Qun Chen, Kenneth Dole, Dominique Blanc, Lawrence Whalen, Daniel Gould, Zheng Huang

Proceedings Volume 6139, 61390K (2006) https://doi.org/10.1117/12.646317

KEYWORDS: Nerve, Photodynamic therapy, Tissues, Electrodes, Prostate cancer, Prostate, Instrument modeling, Connective tissue, Arteries, Tumor growth modeling

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Proceedings Article | 23 February 2006 Paper

Innovative approaches of clinical photodynamic therapy combined with immunotherapy

Zheng Huang

Proceedings Volume 6087, 608708 (2006) https://doi.org/10.1117/12.646402

KEYWORDS: Photodynamic therapy, Tumors, Skin cancer, Melanoma, Photosensitizer targeting, Cancer, Photonic integrated circuits, Oncology, Solids, Pathogens

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Proceedings Article | 10 February 2006 Paper

Light and immune systems: activation of immunological activities

Zheng Huang, Hong Liu, Wei Chen

Proceedings Volume 6087, 608701 (2006) https://doi.org/10.1117/12.644842

KEYWORDS: Tumors, Photodynamic therapy, Tissues, Cancer, Oncology, Therapeutics, Spleen, Laser tissue interaction, Laser therapeutics, Phototherapy

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Proceedings Article | 8 April 2005 Paper

Tookad-mediated photodynamic effects on the prostate and its adjacent tissues: in vivo study in canine models

Zheng Huang, Qun Chen, David Luck, Jill Beckers, Dominique Blanc, Fred Hetzel

Proceedings Volume 5689, (2005) https://doi.org/10.1117/12.587872

KEYWORDS: Photodynamic therapy, Prostate, Tissues, Colon, Bladder, Prostate cancer, Nerve, Diffusers, Phase modulation, Light scattering

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Proceedings Article | 18 January 2005 Paper

Studies of vascular acting photosensitizer Tookad for the photodynamic therapy of prostate cancer

Zheng Huang, Qun Chen, Dominique Blanc, Fred Hetzel

Proceedings Volume 5630, (2005) https://doi.org/10.1117/12.570280

KEYWORDS: Photodynamic therapy, Prostate, Prostate cancer, Tissues, Plasma, Animal model studies, Blood pressure, Blood, Surgery, Tumor growth modeling

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Proceedings Article | 13 July 2004 Paper

A novel image-guided high-intensity focused ultrasound system for tumor treatment

Zhiqiang Wu, Puwei Wu, Bojie Chen, Jian Guan, Zheng Huang

Proceedings Volume 5312, (2004) https://doi.org/10.1117/12.528624

KEYWORDS: Ultrasonography, Transducers, Tissues, Liver, Tumors, Imaging systems, In vitro testing, Motion controllers, Image visualization, Image registration

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Proceedings Article | 14 June 2004 Paper

Preclinical studies of vascular acting photosensitizer bacteriopheophorbide for the treatment of prostate cancer

Fred Hetzel, Qun Chen, David Luck, Jill Beckers, Zheng Huang

Proceedings Volume 5315, (2004) https://doi.org/10.1117/12.528379

KEYWORDS: Photodynamic therapy, Prostate, Prostate cancer, Tissues, Magnetic resonance imaging, Blood, Animal model studies, Bladder, Diffusers, Semiconductor lasers

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Proceedings Article | 8 December 2003 Paper

Studies of a novel photosensitizer Pd-bacteriopheophorbide (Tookad) for the prostate cancer PDT in canine model

Zheng Huang, Qun Chen, Pierre-Herve Brun, Brian Wilson, Avigdor Scherz, Yoram Salomon, David Luck, Jill Beckers, Fred Hetzel

Proceedings Volume 5254, (2003) https://doi.org/10.1117/12.546099

KEYWORDS: Photodynamic therapy, Prostate, Tissues, Prostate cancer, Animal model studies, Tumor growth modeling, Cancer, Blood, Bladder, Colon

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Proceedings Article | 13 June 2003 Paper

Effects of TOOKAD-PDT on canine prostates pre-treated with ionizing radiation

Qun Chen, Zheng Huang, David Luck, Jill Beckers, Nadira Trncic, Susan LaRue, Pierre-Herve Brun, Brian Wilson, Fred Hetzel

Proceedings Volume 4952, (2003) https://doi.org/10.1117/12.474099

KEYWORDS: Photodynamic therapy, Prostate, Tissues, Tissue optics, Ionizing radiation, Surgery, Radiotherapy, Prostate cancer, Bladder, Collagen

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PDT in prostate cancer will likely be implemented clinically with patients who have failed prior ionizing radiation therapy (RT). The current study is to develop an in vivo model to evaluate the effects of PDT on prostatic tissue after RT. To produce a physiological and anatomical environment in prostate similar to that in patients who have failed RT, canine prostates (n=4) were subjected to a definitive course of ionizing radiation therapy (2.7 Gy x 20 fractions) 5 to 6 months prior to PDT. A laparotomy was performed to expose the prostate for PDT. Second generation photosensitizer Tookad (Palladium-Bacteriopheophorbide, Steba Biotech, The Netherlands) acts primarily on tissue vasculature and is very effective in destroying normal prostatic tissue, as shown by our prior studies. Due to the extremely fast clearance of the photosensitizer, interstitial light irradiation (760 nm, 50-200 J/cm, 150 mW/cm from a 1 cm diffuser fiber) was delivered 4 minutes after the onset of Tookad infusion (i.v. 2.5 mg/ml, 2 mg/kg, total infusion time 10 min). The prostates were harvested for histopathology one week after PDT. At one week, the lesions were characterized by acute hemorrhagic necrosis with patchy sub-capsular hyperemia and edema. The maximum lesion diameter for 50, 100 and 200 J/cm PDT was approximately 15, 20 and 28 mm, respectively. The lesion size is well correlated with light fluence and comparable to that in prostates treated with identical PDT doses but without prior-RT. Under light-microscopy, the PDT induced necrosis is clearly distinguishable from the radiation induced fibrosis. No urethral lesions were observed. Dyer’s Verhoeff stain showed the loss of stromal connective tissue and the acinar collagen in the PDT treated area. There was no noticeable damage on the bladder or underlying colon section. In conclusion, Tookad-PDT can effectively destroy prostate tissue with prior-RT induced fibrosis, thus, may provide an alternative modality for those prostate-cancer patients who have failed RT.

Proceedings Article | 13 June 2003 Paper

Studies of a novel photosensitizer palladium-bacteriopheophorbide (Tookad) for the treatment of prostate cancer

Zheng Huang, Qun Chen, Pierre-Herve Brun, Brian Wilson, Avigdor Scherz, Yoram Salomon, David Luck, Jill Beckers, Fred Hetzel

Proceedings Volume 4952, (2003) https://doi.org/10.1117/12.474097

KEYWORDS: Photodynamic therapy, Prostate, Tissues, Prostate cancer, Animal model studies, Blood, Tumors, Bladder, Blood pressure, Cancer

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Proceedings Article | 13 June 2003 Paper

Hyperoxygenation enhances the direct tumor cell killing of photofrin-mediated photodynamic therapy

Zheng Huang, Qun Chen, Abdus Shakil, Hua Chen, Jill Beckers, Howard Shapiro, Fred Hetzel

Proceedings Volume 4952, (2003) https://doi.org/10.1117/12.474147

KEYWORDS: Tumors, Photodynamic therapy, Oxygen, Tissues, In vitro testing, Hypoxia, Animal model studies, In vivo imaging, Tissue optics, Sensors

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Proceedings Article | 12 September 2002 Paper

Improvement of tumor response to photodynamic therapy by manipulation of tumor oxygenation in an in-vivo model system

Qun Chen, Zheng Huang, Hua Chen, Howard Shapiro, Jill Beckers, Fred Hetzel

Proceedings Volume 4916, (2002) https://doi.org/10.1117/12.482964

KEYWORDS: Tumors, Photodynamic therapy, Oxygen, Tissues, Hypoxia, Tissue optics, Electrodes, Animal model studies, Tumor growth modeling, Systems modeling

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Proceedings Article | 6 June 2002 Paper

WSTO9 (TOOKAD) mediated photodynamic therapy as an alternative modality in the treatment of prostate cancer

Qun Chen, Zheng Huang, David Luck, Jill Beckers, Pierre-Herve Brun, Brian Wilson, Avigdor Scherz, Yoram Salomon, Fred Hetzel

Proceedings Volume 4612, (2002) https://doi.org/10.1117/12.469351

KEYWORDS: Photodynamic therapy, Prostate, Prostate cancer, Tissues, Tissue optics, Bladder, Colon, Animal model studies, Surgery, Tumors

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Showing 5 of 57 publications

Proceedings Volume Editor (1)

SPIE Conference Volume | 3 October 2014

Twelfth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2014)

Conference Committee Involvement (16)

17th International Photodynamic Association World Congress

28 June 2019 | Cambridge, United States

Translation of Lasers and Biophotonics Technologies and Procedures: Toward the Clinic

23 June 2019 | Munich, Germany

Biophotonics and Immune Responses XIII

29 January 2018 | San Francisco, California, United States

Biophotonics and Immune Responses XII

30 January 2017 | San Francisco, California, United States

Biophotonics and Immune Responses XI

15 February 2016 | San Francisco, California, United States

Biophotonics and Immune Responses X

9 February 2015 | San Francisco, California, United States

Twelfth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2014)

14 June 2014 | Wuhan, China

Biophotonics and Immune Responses IX

3 February 2014 | San Francisco, California, United States

Biophotonics and Immune Responses VIII

4 February 2013 | San Francisco, California, United States

Biophotonics and Immune Responses VII

23 January 2012 | San Francisco, California, United States

Biophotonics and Immune Responses VI

24 January 2011 | San Francisco, California, United States

Biophotonics and Immune Responses V

25 January 2010 | San Francisco, California, United States

Biophotonics and Immune Responses IV

25 January 2009 | San Jose, California, United States

Biophotonics and Immune Responses III

21 January 2008 | San Jose, California, United States

Biophotonics and Immune Responses II

22 January 2007 | San Jose, California, United States

Biophotonics and Immune Responses

23 January 2006 | San Jose, California, United States

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