Prof. Avigdor Scherz Profile

Prof. Avigdor Scherz

at Weizmann Institute of Science

SPIE Involvement:

Author

Proceedings Article | 14 August 2019 Presentation

Vascular targeted photodynamic therapy with Tookad: from local ablation to systemic cancer treatment (Conference Presentation)

Avigdor Scherz, Lilach Agemi, Dina Preise, Rachel Elmoalem-Hamri, Jonathan Coleman

Proceedings Volume 11070, 1107035 (2019) https://doi.org/10.1117/12.2527629

KEYWORDS: Cancer, Photodynamic therapy, Oncology, Therapeutics, Tumors, Modulation, Prostate cancer, Esophagus, Prostate, Genomics

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Vascular targeted photodynamic therapy with TOOKAD-from local ablation to systemic cancer treatment Background: Local therapies that allow for safe ablation of primary lesions and trigger anti-tumor immunity with minimal side effects, may be particularly effective in management of early-stage cancer. Vascular-targeted photodynamic therapy (VTP) with TOOKAD®, recently granted EMA approval as a first-line treatment for localized prostate cancer, has been shown by us to also trigger anti-tumor immunity. Our recent preclinical and current clinical studies aim to test the hypothesis that synchronizing TOOKAD®VTP with immune-modulation that attenuates the pro-tumor immunity, will result in systemic micrometastases annihilation and a high cure rate. Methods: 4T1-Luc, adenosquamous JA and Met-Lu cells were orthotopically grafted in the mammary pad, esophagus and prostate of immune-competent mice and rats, respectively. Seven days postgrafting, tumors were treated with TOOKAD®VTP, with or without immune-modulators. Immune profiles were examined by 10-X genomics, FACS analysis and immunohistochemistry. Animal survival and lung and lower abdomen metastases counts were followed up for 3 months. Clinical protocols were composed based on the preclinical data and utilized in the clinical studies that will be described in other lectures of this session. Results: TOOKAD®VTP triggered anti-tumor immunity sufficient to achieve 60-90% cure in various cancer models. However, primary lesion annihilation did not prevent disease progression in the more aggressive cancers such as 4T1-Luc breast cancer. TOOKAD®VTP synchronized with metronomic administration of immune-modulators was associated with a 60-90% disease-free animals and resistance to re-challenge. The rate of success was highly pending on the exact synchronization of the immune modulating agents with the VTP timing. The required modulators match the deciphered immune profiles. This combined immuno-VTP therapy concept has been translated to clinical trials currently ongoing at Memorial Sloan Kettering Cancer Center. Conclusion: Application of TOOKAD®VTP to localized tumors combined with immune modulation appears to provide novel means to treat early disseminated cancers.

Proceedings Article | 8 February 2017 Presentation + Paper

Real time laser speckle imaging monitoring vascular targeted photodynamic therapy

Ruth Goldschmidt, Kalchenko Vyacheslav, Avigdor Scherz

Proceedings Volume 10047, 100470M (2017) https://doi.org/10.1117/12.2251971

KEYWORDS: Photodynamic therapy, Blood vessels, Blood circulation, Laser speckle imaging, Cancer, Arteries, Veins, Real time imaging, Laser therapeutics, Speckle, In vivo imaging, Laser skin treatment, Tumors, Ear, Tissues, Blood

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Proceedings Article | 7 December 2006 Paper

In vivo evaluation of accumulation of sensitizers for oncological diagnostics and therapy using the method of diffuse reflectance spectroscopy

I. Meerovich, A. Stratonnikov, A. Ryabova, G. Meerovich, N. Oborotova, A. Brandis, E. Lukyanets, O. Kaliya, P. Bendel, V. Loschenov, A. Scherz, A. Baryshnikov

Proceedings Volume 5973, 59730H (2006) https://doi.org/10.1117/12.640052

KEYWORDS: Absorption, Tumors, Tissues, In vivo imaging, Tissue optics, Diagnostics, Diffuse reflectance spectroscopy, Biological research, Photodynamic therapy, Manganese

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Proceedings Article | 7 December 2006 Paper

Fluorescent and photodynamic properties of near-infrared photosensitizer bacteriochlorophyllide-serine

I. Meerovich, I. Kubasova, N. Oborotova, G. Meerovich, S. Demura, A. Brandis, V. Rosenbach-Belkin, A. Baryshnikov, A. Scherz

Proceedings Volume 5973, 59730G (2006) https://doi.org/10.1117/12.640051

KEYWORDS: Tumors, Luminescence, Tissues, Photodynamic therapy, Picosecond phenomena, Tissue optics, Semiconductor lasers, Optical filters, Blood, Transparency

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Proceedings Article | 21 June 2004 Paper

Fluorescent and photodynamic properties of infrared photosensitizer bacteriochlorophyllide-serine

I. Meerovich, Irina Kubasova, Gennadii Meerovich, Alexander Stratonnikov, S. Demura, Alexandr Brandis, V. Rosenbach-Belkin, Avigdor Scherz

Proceedings Volume 5449, (2004) https://doi.org/10.1117/12.563144

KEYWORDS: Tumors, Luminescence, Photodynamic therapy, Tissues, Tissue optics, Semiconductor lasers, Blood, In vivo imaging, Infrared photography, Infrared radiation

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Proceedings Article | 8 December 2003 Paper

Studies of a novel photosensitizer Pd-bacteriopheophorbide (Tookad) for the prostate cancer PDT in canine model

Zheng Huang, Qun Chen, Pierre-Herve Brun, Brian Wilson, Avigdor Scherz, Yoram Salomon, David Luck, Jill Beckers, Fred Hetzel

Proceedings Volume 5254, (2003) https://doi.org/10.1117/12.546099

KEYWORDS: Photodynamic therapy, Prostate, Tissues, Prostate cancer, Animal model studies, Tumor growth modeling, Cancer, Blood, Bladder, Colon

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Proceedings Article | 13 June 2003 Paper

Studies of a novel photosensitizer palladium-bacteriopheophorbide (Tookad) for the treatment of prostate cancer

Zheng Huang, Qun Chen, Pierre-Herve Brun, Brian Wilson, Avigdor Scherz, Yoram Salomon, David Luck, Jill Beckers, Fred Hetzel

Proceedings Volume 4952, (2003) https://doi.org/10.1117/12.474097

KEYWORDS: Photodynamic therapy, Prostate, Tissues, Prostate cancer, Animal model studies, Blood, Tumors, Bladder, Blood pressure, Cancer

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Proceedings Article | 6 June 2002 Paper

WSTO9 (TOOKAD) mediated photodynamic therapy as an alternative modality in the treatment of prostate cancer

Qun Chen, Zheng Huang, David Luck, Jill Beckers, Pierre-Herve Brun, Brian Wilson, Avigdor Scherz, Yoram Salomon, Fred Hetzel

Proceedings Volume 4612, (2002) https://doi.org/10.1117/12.469351

KEYWORDS: Photodynamic therapy, Prostate, Prostate cancer, Tissues, Tissue optics, Bladder, Colon, Animal model studies, Surgery, Tumors

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Showing 5 of 8 publications

Conference Committee Involvement (1)

17th International Photodynamic Association World Congress

28 June 2019 | Cambridge, Massachusetts, United States

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