Dr. Yan Liu Profile

Dr. Yan Liu

SPIE Involvement:

Author

Area of Expertise:

Wavefront shaping , Optical phase conjugation , Focusing light inside scattering media , Adaptive optics , Optical coherence tomography , Deep tissue optical imaging and focusing

Websites:

Personal Website

Profile Summary

Dr. Yan Liu is a research associate in Prof. Donald Miller's group at Indiana University. Before that, he was a postdoc in Prof. Changhuei Yang's group at California Institute of Technology (Caltech). Yan received his Ph.D. degree in Biomedical Engineering at Washington University, under the mentorship of Prof. Lihong V. Wang (now a professor at Caltech). He obtained his Bachelor's degree at Tsinghua University. Yan has done research in adaptive optics OCT, wavefront shaping, photoacoustic imaging, ultrasound-modulated optical tomography and fluorescence imaging. For more information, please visit his website through https://yan-liu.wixsite.com/mysite.

Publications (28)

Proceedings Article | 13 March 2024 Presentation

Presentation

In vivo AO-OCT spectral sensitivity and photopigment density measurements of human cone and rod photoreceptors

Marcel Bernucci, Yan Liu, James Crowell, Qiuzhi Ji, Donald Miller

Proceedings Volume PC12824, PC128240N (2024) https://doi.org/10.1117/12.3003331

KEYWORDS: Adaptive optics optical coherence tomography, Cones, Rods, Spectral density, In vivo imaging, Visible radiation, Video, Retina, High power lasers, Eye

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Proceedings Article | 13 March 2024 Presentation + Paper

Presentation + Paper

An integrated fixation and stimulus channel for adaptive optics ophthalmoscopy with a large working distance, steering field, dioptric range, and light efficiency

Yan Liu, Marcel Bernucci, Qiuzhi Ji, James Crowell, Kristen Bowles-Johnson, Matthew Keller, Donald Miller

Proceedings Volume 12824, 1282402 (2024) https://doi.org/10.1117/12.3003262

KEYWORDS: Eye, Adaptive optics, Adaptive optics optical coherence tomography, Retina, Design, Ophthalmoscopy, Dichroic mirrors, Imaging systems

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Proceedings Article | 13 March 2024 Presentation + Paper

Presentation + Paper

Method for assessing structure and function of cone photoreceptors with multiple outer segment reflections in healthy and diseased eyes

Qiuzhi Ji, Yan Liu, Marcel Bernucci, James Crowell, Donald Miller

Proceedings Volume 12824, 1282407 (2024) https://doi.org/10.1117/12.3003241

KEYWORDS: Reflection, Cones, Adaptive optics optical coherence tomography, Control systems, Retina, Spectral response, Image segmentation, Optical coherence tomography, Adaptive optics, Eye

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Proceedings Article | 5 January 2024 Open Access

Open Access

Paper

Photopigment density variation of individual cone photoreceptors revealed by phase-sensitive AO-OCT (Erratum)

Marcel Bernucci, Yan Liu, James Crowell, Kazuhiro Kurokawa, Qiuzhi Ji, Donald Miller

Proceedings Volume 12360, 1236010 (2024) https://doi.org/10.1117/12.3025262

KEYWORDS: Adaptive optics optical coherence tomography, Cones, Retina

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Proceedings Article | 15 March 2023 Presentation + Paper

Presentation + Paper

Low-latency, photon-efficient wavefront sensing for ultrafast adaptive optics imaging of the human retina

Yan Liu, James Crowell, Kazuhiro Kurokawa, Marcel Bernucci, Qiuzhi Ji, Ayoub Lassoued, Hae Won Jung, Donald Miller

Proceedings Volume 12360, 123600A (2023) https://doi.org/10.1117/12.2650674

KEYWORDS: Adaptive optics, Wavefront sensors, Wavefront errors, Photons, Eye, Wavefront aberrations, Cameras, Adaptive optics optical coherence tomography, Optical coherence tomography

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Proceedings Article | 15 March 2023 Presentation + Paper

Presentation + Paper

S-cone identification using AO-OCT cone structural measurements and support vector machine classifier

Qiuzhi Ji, Marcel Bernucci, Yan Liu, James Crowell, Davin Miller, Donald Miller

Proceedings Volume 12360, 1236005 (2023) https://doi.org/10.1117/12.2650609

KEYWORDS: Cones, Adaptive optics optical coherence tomography, Reflection, Image segmentation, Reflectivity, Retina, Support vector machines, Eye, Adaptive optics, Video

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Proceedings Article | 15 March 2023 Presentation + Paper

Presentation + Paper

Photopigment density variation of individual cone photoreceptors revealed by phase-sensitive AO-OCT

Marcel Bernucci, Yan Liu, James Crowell, Kazuhiro Kurokawa, Qiuzhi Ji, Donald Miller

Proceedings Volume 12360, 1236006 (2023) https://doi.org/10.1117/12.2649489

KEYWORDS: Cones, Adaptive optics optical coherence tomography, Spectral density, Spectral response, Histograms, Visible radiation, Retina, Retinal diseases, Resolution enhancement technologies, In vivo imaging

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Numerous retinal pathologies affect cone photoreceptor photopigment density, making it a potentially attractive functional biomarker for detecting and tracking disease progression. Conventional methods to measure photopigment density include psychophysical color matching, microspectrophotometry, and retinal densitometry, but these are either subjective, measure the aggregate response/change of thousands of cones, or are performed ex vivo. Recently, we have developed a method to measure spectral sensitivities of individual human cone photoreceptors objectively, non-invasively, and in vivo with adaptive optics optical coherence tomography (AO-OCT). In preliminary results we have observed variability in the spectral sensitivities of individual cones of the same type (S, M or L) that we hypothesize attributes to inter-cone variations in photopigment density. If correct, this may be of significant clinical interest. Here, we test this hypothesis by (1) deriving an expression for the relative photopigment densities of individual cone photoreceptors based on a theoretical model of the cone absorption process and (2) using this expression to estimate photopigment density from our AO-OCT measurements of spectral sensitivity. Our mean spectral sensitivity measurements align well to Stockman & Sharpe’s well-recognized cone fundamentals with a total least-squared error of 0.12 and confidence intervals (CI) <0.36, <0.025 and <0.017 for S, M, and L cones, respectively. The substantive variability in individual cone spectral sensitivities once related to photopigment density exhibits a distribution of standard deviation=0.177 for a group of 703 cones. This indicates a two-fold difference in light sensitivity between the least sensitive cone (least amount of photopigment) and the most sensitive cone (largest amount of photopigment) for 95% of the cones measured. Furthermore, we found relative photopigment density decreased with increasing retinal eccentricity from nasal to temporal retina at 3.8° eccentricity with a slope of -0.24/° (p < .001). Both density distribution and eccentricity dependence are consistent with the literature.

Proceedings Article | 5 March 2021 Presentation

Presentation

Noninvasive method to objectively measure the spectral sensitivity of individual cone photoreceptors using AO-OCT

Marcel Bernucci, Kazuhiro Kurokawa, Furu Zhang, Yan Liu, James Crowell, Donald Miller

Proceedings Volume 11623, 1162312 (2021) https://doi.org/10.1117/12.2578429

KEYWORDS: Cones, Adaptive optics optical coherence tomography, Visible radiation, Spectral resolution, Retina, In vivo imaging, Eye, Color vision

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Proceedings Article | 5 March 2021 Presentation

Presentation

Ultrafast adaptive optics for imaging the living human retina

Yan Liu, James Crowell, Kazuhiro Kurokawa, Ayoub Lassoued, Hae Won Jung, Marcel Bernucci, Donald Miller

Proceedings Volume 11623, 1162307 (2021) https://doi.org/10.1117/12.2578701

KEYWORDS: Adaptive optics

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Proceedings Article | 5 March 2021 Presentation

Presentation

Fluorescence imaging through dynamic scattering media with and without using wavefront shaping

Yan Liu, Haowen Ruan, Jian Xu, Yujia Huang, Changhuei Yang

Proceedings Volume 11652, 116520N (2021) https://doi.org/10.1117/12.2583282

KEYWORDS: Luminescence, Ultrasonography, Speckle, Scattering media, Modulation, Scattering, Tissues, Optical imaging, Light scattering, In vivo imaging

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SPIE Journal Paper | 26 February 2020 Open Access

Open Access

Investigating ultrasound–light interaction in scattering media

Yujia Huang, Michelle Cua, Joshua Brake, Yan Liu, Changhuei Yang

JBO, Vol. 25, Issue 02, 025002, (February 2020) https://doi.org/10.1117/12.10.1117/1.JBO.25.2.025002

KEYWORDS: Ultrasonography, Modulation, Light scattering, Particles, Scattering, Photons, Scattering media, Refractive index, Monte Carlo methods, Speckle

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Proceedings Article | 19 February 2020 Paper

Paper

Measuring dysfunction of cone photoreceptors in retinitis pigmentosa with phase-sensitive AO-OCT

Ayoub Lassoued, Furu Zhang, Kazuhiro Kurokawa, Yan Liu, James Crowell, Donald Miller

Proceedings Volume 11218, 1121815 (2020) https://doi.org/10.1117/12.2550216

KEYWORDS: Cones, Adaptive optics optical coherence tomography, Control systems, Optical coherence tomography, Image segmentation, Eye, Light emitting diodes, Retina, Video, Adaptive optics

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Proceedings Article | 4 March 2019 Presentation

Presentation

Time-reversed ultrasonically encoded (TRUE) optical focusing through highly scattering ex vivo human cataractous lenses for congenital cataract treatment (Conference Presentation)

Yan Liu, Yuecheng Shen, Haowen Ruan, Frank Brodie, Terence T. Wong, Changhuei Yang, Lihong Wang

Proceedings Volume 10886, 1088602 (2019) https://doi.org/10.1117/12.2508994

KEYWORDS: Scattering, Lenses, Surgery, Retina, Light scattering, Wavefronts, Visual system, Opacity, Visualization

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Proceedings Article | 15 March 2018 Presentation

Presentation

Applying sub-Nyquist sampling in optical time-reversal-based wavefront shaping to boost targeted light transport through opaque scattering media (Conference Presentation)

Yuecheng Shen, Yan Liu, Cheng Ma, Lihong Wang

Proceedings Volume 10502, 105020Z (2018) https://doi.org/10.1117/12.2287064

KEYWORDS: Wavefronts, Light scattering, Opacity, Scattering media, Biomedical optics, Optical imaging, Phase conjugation, Tissue optics, Adaptive optics, Holographic interferometry

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Proceedings Article | 14 March 2018 Presentation

Presentation

High-speed single-shot optical focusing through dynamic turbid media (Conference Presentation)

Ashton Hemphill, Yuecheng Shen, Yan Liu, Lihong Wang

Proceedings Volume 10502, 105020M (2018) https://doi.org/10.1117/12.2289306

KEYWORDS: Tissue optics, Soft tissue optics, Light scattering, Wavefronts, Biomedical optics, Adaptive optics, Phase conjugation, Holography, Scattering, Speckle

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Proceedings Article | 14 March 2018 Presentation

Presentation

Focusing light through scattering media by polarization modulation based generalized digital optical phase conjugation (Conference Presentation)

Jiamiao Yang, Yuecheng Shen, Yan Liu, Ashton Hemphill, Lihong Wang

Proceedings Volume 10502, 105020L (2018) https://doi.org/10.1117/12.2287467

KEYWORDS: Modulation, Tissue optics, Polarization, Light scattering, Wavefronts, Scattering media, Phase conjugation, Spatial light modulators, Biomedical optics, Scattering

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Proceedings Article | 23 February 2018 Presentation + Paper

Presentation + Paper

Time-reversed ultrasonically encoded (TRUE) focusing for deep-tissue optogenetic modulation

Joshua Brake, Haowen Ruan, J. Elliott Robinson, Yan Liu, Viviana Gradinaru, Changhuei Yang

Proceedings Volume 10502, 1050210 (2018) https://doi.org/10.1117/12.2288331

KEYWORDS: Phase conjugation, Tissue optics, Light scattering, Brain, Optogenetics, Scattering, Modulation, Wavefronts, Tissues, Neurons

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SPIE Journal Paper | 10 January 2018 Open Access

Open Access

Time-reversed ultrasonically encoded optical focusing through highly scattering ex vivo human cataractous lenses

Yan Liu, Yuecheng Shen, Haowen Ruan, Frank L. Brodie, Terence T. W. Wong, Changhuei Yang, Lihong V. Wang

JBO, Vol. 23, Issue 01, 010501, (January 2018) https://doi.org/10.1117/12.10.1117/1.JBO.23.1.010501

KEYWORDS: Wavefronts, Light scattering, Scattering, Retina, Spatial light modulators, Surgery, Ultrasonics, Tissue optics, Lenses, Cameras

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Proceedings Article | 24 April 2017 Presentation

Presentation

Focusing light inside dynamic scattering media with millisecond digital optical phase conjugation (Conference Presentation)

Yan Liu, Cheng Ma, Yuecheng Shen, Lihong Wang

Proceedings Volume 10073, 100730F (2017) https://doi.org/10.1117/12.2250042

KEYWORDS: Dynamic light scattering, Field programmable gate arrays, Diffusers, Phase conjugation, Tissue optics, Scattering media, Wavefronts, Light scattering, Spatial light modulators, Digital micromirror devices

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Proceedings Article | 21 February 2017 Presentation + Paper

Presentation + Paper

Optical focusing through biological tissue and tissue-mimicking phantoms up to 9.6 centimeters thick with digital optical phase conjugation

Yuecheng Shen, Yan Liu, Cheng Ma, Lihong Wang

Proceedings Volume 10073, 100730G (2017) https://doi.org/10.1117/12.2251052

KEYWORDS: Tissue optics, Biomedical optics, Adaptive optics, Light scattering, Phase conjugation, Optical proximity correction, Scattering media, Laser tissue interaction, Optical imaging, Wavefronts, Scattering, Laser scattering, Speckle, Photons

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SPIE Journal Paper | 12 August 2016 Open Access

Open Access

Focusing light through biological tissue and tissue-mimicking phantoms up to 9.6 cm in thickness with digital optical phase conjugation

Yuecheng Shen, Yan Liu, Cheng Ma, Lihong Wang

JBO, Vol. 21, Issue 08, 085001, (August 2016) https://doi.org/10.1117/12.10.1117/1.JBO.21.8.085001

KEYWORDS: Tissue optics, Wavefronts, Optical proximity correction, Scattering, Light scattering, Laser scattering, Signal to noise ratio, Cameras, Phase measurement, Phase conjugation

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Proceedings Article | 27 April 2016 Presentation

Presentation

Bit-efficient sub-millisecond wavefront measurement using a lock-in camera for time-reversal based optical focusing inside scattering media (Conference Presentation)

Yan Liu, Cheng Ma, Yuecheng Shen, Lihong Wang

Proceedings Volume 9717, 97171J (2016) https://doi.org/10.1117/12.2211936

KEYWORDS: Cameras, Wavefronts, Scattering media, Biomedical optics, Optical imaging, Ultrasonics, Holography, Data conversion, Digital holography, Imaging systems

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Proceedings Article | 4 March 2014 Paper

Paper

Sub-diffraction-limited imaging by photobleaching imprinting microscopy

Liang Gao, Alejandro Garcia-Uribe, Yan Liu, Chiye Li, Lihong Wang

Proceedings Volume 8950, 895015 (2014) https://doi.org/10.1117/12.2038573

KEYWORDS: Microscopy, Luminescence, Super resolution, Microscopes, Confocal microscopy, Diffraction, Image resolution, Signal to noise ratio, Point spread functions, Lithium

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Proceedings Article | 3 March 2014 Paper

Paper

High-speed time-reversed ultrasonically encoded (TRUE) optical focusing inside dynamic scattering media at 793 nm

Yan Liu, Puxiang Lai, Cheng Ma, Xiao Xu, Yuta Suzuki, Alexander Grabar, Lihong Wang

Proceedings Volume 8943, 894339 (2014) https://doi.org/10.1117/12.2039815

KEYWORDS: Speckle, Tissue optics, Scattering media, Signal detection, Phase conjugation, Crystals, Light scattering, Ultrasonography, Holography, Speckle pattern

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Proceedings Article | 4 March 2013 Paper

Paper

Single-cell photoacoustic thermometry

Liang Gao, Lidai Wang, Chiye Li, Yan Liu, Haixin Ke, Chi Zhang, Lihong Wang

Proceedings Volume 8581, 858118 (2013) https://doi.org/10.1117/12.2004063

KEYWORDS: Photoacoustic spectroscopy, Temperature metrology, Thermometry, Acoustics, Image resolution, Ultrasonography, Calibration, Absorption, Cancer, Biosensors

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SPIE Journal Paper | 1 February 2013 Open Access

Open Access

Single-cell photoacoustic thermometry

Liang Gao, Lidai Wang, Chiye Li, Yan Liu, Haixin Ke, Chi Zhang, Lihong Wang

JBO, Vol. 18, Issue 02, 026003, (February 2013) https://doi.org/10.1117/12.10.1117/1.JBO.18.2.026003

KEYWORDS: Photoacoustic spectroscopy, Temperature metrology, Thermometry, Calibration, Pulsed laser operation, Particles, Acoustics, Image resolution, Cancer, Imaging systems

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SPIE Journal Paper | 11 December 2012 Open Access

Open Access

Effects of light scattering on optical-resolution photoacoustic microscopy

Yan Liu, Chi Zhang, Lihong Wang

JBO, Vol. 17, Issue 12, 126014, (December 2012) https://doi.org/10.1117/12.10.1117/1.JBO.17.12.126014

KEYWORDS: Point spread functions, Monte Carlo methods, Scattering, Light scattering, Tissue optics, Acoustics, Transducers, Signal detection, Photons, Capillaries

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Proceedings Article | 23 February 2012 Paper

Paper

Effect of light scattering on optical-resolution photoacoustic microscopy

Yan Liu, Chi Zhang, Song Hu, Yuta Suzuki, Zhun Xu, Silvina Ferradal, Lihong Wang

Proceedings Volume 8223, 82233S (2012) https://doi.org/10.1117/12.909373

KEYWORDS: Point spread functions, Light scattering, Acoustics, Transducers, Monte Carlo methods, Photoacoustic microscopy, Optical resolution, Signal detection, Absorption, Signal generators

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Showing 5 of 28 publications

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