Validation of a real-time navigation system for pleural photodynamic therapy with 3D-printed lung phantom and various optical properties

Hongjing Sun; Dennis Sourvanos; Brook Byrd; Timothy C. Zhu

doi:10.1117/12.3002927

12 March 2024 Validation of a real-time navigation system for pleural photodynamic therapy with 3D-printed lung phantom and various optical properties

Hongjing Sun, Dennis Sourvanos, Brook Byrd, Timothy C. Zhu

Author Affiliations +

Proceedings Volume 12823, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXXII; 1282307 (2024) https://doi.org/10.1117/12.3002927
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Intraoperative photodynamic therapy (PDT) has proven effective in treating malignant pleural mesothelioma. Achieving uniform light dose delivery is vital for its efficiency. Currently, eight light detectors are placed inside the pleural cavity to monitor light distribution. To enhance this process, an updated navigation system, combined with a novel scanning system, has been developed to provide real-time guidance to physicians during pleural PDT, thereby improving light delivery. The scanning system incorporates two handheld three-dimensional (3D) scanners, enabling rapid and precise capture of the pleural cavity's surface topography before PDT. This allows for identification of the target surface for real-time calculation of light fluence distribution during treatment. An algorithm has been devised to further process the scanned volume, facilitating continuous tracking of the light source position within the pleural cavity throughout the treatment process. During PDT, real-time 3D and 2D visualizations of the light source position, scanned pleural cavity, and light fluence distribution across the entire cavity's surface are displayed, providing physicians with invaluable guidance to enhance overall treatment efficiency. To validate the system, phantom studies were conducted using three newly 3D-printed lung phantoms of varying volumes based on individual CT scans. A set of liquid tissue-simulating phantoms with different combinations of optical properties (μ_a, μ_s') was utilized for improved clinical simulation. These lung phantoms, designed to mimic surgical conditions, feature side openings similar to the actual surgery and are treated with eight isotropic detectors fixed on the inner surface at positions predetermined by the physician.

Conference Presentation

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Hongjing Sun, Dennis Sourvanos, Brook Byrd, and Timothy C. Zhu "Validation of a real-time navigation system for pleural photodynamic therapy with 3D-printed lung phantom and various optical properties", Proc. SPIE 12823, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXXII, 1282307 (12 March 2024); https://doi.org/10.1117/12.3002927

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