Dr. Brandon Gaitan Profile

Dr. Brandon Gaitan

Graduate Student at Univ of Maryland College Park

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Author

Publications (9)

Proceedings Article | 8 April 2024 Presentation

Fluorescence-guided photoimmunotherapy for peritoneal carcinomatosis

Barry Liang, Sumiao Pang, Robert Perttila, Chen-Hua Ma, Payal Srivastava, Brandon Gaitan, Aaron Sorrin, Nada Fadul, Idrisa Rahman, Zoe Ylöniemi, Dana Roque, Tayyaba Hasan, Petteri Uusimaa, Huang-Chiao Huang

Proceedings Volume PC12823, PC128230D (2024) https://doi.org/10.1117/12.3011885

KEYWORDS: Photoimmunotherapy, Photonic integrated circuits, Mouse models, Chemotherapy, Tumors, Resistance, Resection, Photomedicine, Ovarian cancer, Nanotechnology

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Proceedings Article | 17 March 2023 Presentation

Fluorescence-guided, targeted photochemotherapy of peritoneal carcinomatosis

Barry Liang, Robert Perttilä, Sumiao Pang, Chen-Hua Ma, Payal Srivastava, Brandon Gaitan, Aaron Sorrin, Zoe Ylöniemi, Dana Roque, Tayyaba Hasan, Petteri Uusimaa, Huang-Chiao Huang

Proceedings Volume PC12359, PC123590A (2023) https://doi.org/10.1117/12.2657053

KEYWORDS: Tumors, Ovarian cancer, Oncology, Mouse models, Luminescence, Laser systems engineering, Laser development, LASIK, Cancer, Abdomen

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Proceedings Article | 17 March 2023 Presentation

Test method for evaluating the photocytotoxic potential of fluorescence imaging products

Shruti Vig, Brandon Gaitan, Lucas Frankle, Miriam Adwan, Yu Chen, Rosalie Elespuru, Joshua Pfefer, Huang-Chiao Huang

Proceedings Volume PC12359, PC1235908 (2023) https://doi.org/10.1117/12.2652255

KEYWORDS: Luminescence, Safety, Visualization, Tissues, Standards development, Skin, Molecules, In vitro testing

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Proceedings Article | 24 May 2022 Presentation

Clinically relevant pure porphyrin nanoparticles for photodynamic therapy and priming applications

Collin Inglut, Jillian Stable, Brandon Gaitan, Wen-An Chiou, Baktiar Karim, Nina Connolly, Robert Robey, Graeme Woodworth, Michael Gottesman, Huang-Chiao Huang

Proceedings Volume PC12146, PC1214606 (2022) https://doi.org/10.1117/12.2618159

KEYWORDS: Photodynamic therapy, Nanoparticles, Tumors, Plasma display panels, Cancer, Brain, Photomedicine, Luminescence, Animal model studies, Tumor growth modeling

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Liposomes have revolutionized the field of photomedicine. Photodynamic therapy (PDT) using Visudyne®, a liposomal photosensitizer formulation, has helped many patients globally. Since the FDA approved Visudyne® in 2002, countless studies have examined strategies to further improve the therapeutic index of lipid-based photosensitizing nanoconstructs. While liposomes can improve the pharmacokinetics of hydrophobic photosensitizers, they could also modulate cellular uptake and singlet oxygen production. Furthermore, it is evident that there are other immunological and toxicological considerations for the design of liposomal drugs. Accordingly, there is now an emerging trend to engineer carrier-free nanodrugs. Here, we developed a pure-drug nanoparticle using the clinically used verteporfin photosensitizer (termed nanoVP) for photodynamic applications. We validated the effects of nanoVP in three contexts: 1) cytotoxic PDT, 2) subtherapeutic PDT, and 3) dark toxicity. Using a brain cancer murine model, we showed that light activation of nanoVP reduced tumor volume by up to 54% compared to liposomal VP. Fluorescence imaging revealed that nanoVP had a superior tumor-to-liver tissue ratio (~0.92) compared to liposomal VP (~0.4). We further studied nanoVP-mediated PDT at subtherapeutic doses to achieve photodynamic priming (PDP). PDP has been shown to enhance drug delivery, activate antitumor immunity, and sensitize tumors to chemotherapy. This approach is particularly relevant in the brain, where high doses of PDT can result in edema, neurotoxicity, and even animal death. Using a rat model, we demonstrated that nanoVP-assisted PDP improved blood-brain barrier permeability and accumulation of a model drug (Evans Blue dye) in rat brains by >5 fold. Minimal to no brain damage was observed. Lastly, under dark conditions, we validated that nanoVP significantly reduced viability while liposomal VP stimulated cancer cell growth. Results from this work demonstrate the utility of nanoVP for cancer treatment. The development of pure-drug photosensitizing nanoparticles for photodynamic applications could further revolutionize the field of photomedicine.

Proceedings Article | 7 March 2022 Presentation

Development of an in silico NIRS model to inform the development of performance test methods

Brandon Gaitan, Alice Truong, Mousa Moradi, Yu Chen, Joshua Pfefer

Proceedings Volume PC11951, PC1195107 (2022) https://doi.org/10.1117/12.2609971

KEYWORDS: Near infrared spectroscopy, Performance modeling, Monte Carlo methods, Signal detection, Sensors, Reflectivity, Oximeters, Photons, Diffuse reflectance spectroscopy, Computer simulations

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Proceedings Article | 5 March 2021 Presentation

Quantifying the photochemical damage potential of fluorescence contrast agents: singlet oxygen production

Brandon Gaitan, Rosalie Elespuru, Ellen Oskoui, Mariam Adwan, Anqi He, Huang-Chiao Huang, Yu Chen, Joshua Pfefer

Proceedings Volume 11660, 116600A (2021) https://doi.org/10.1117/12.2579521

KEYWORDS: Oxygen, Luminescence, Safety, Molecules, Industrial chemicals, Visualization, Standards development, Optical imaging, Molecular imaging

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SPIE Journal Paper | 26 September 2020 Open Access

Depth-resolved imaging of photosensitizer in the rodent brain using fluorescence laminar optical tomography

Brandon Gaitan, Collin Inglut, Yi Liu, Yu Chen, Huang-Chiao Huang

JBO, Vol. 25, Issue 09, 096007, (September 2020) https://doi.org/10.1117/12.10.1117/1.JBO.25.9.096007

KEYWORDS: Brain, Tissues, Neuroimaging, Luminescence, Signal attenuation, Imaging systems, Optical tomography, Capillaries, 3D image processing, Optical coherence tomography

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Proceedings Article | 20 April 2020 Presentation

Using fluorescence laminar optical tomography to measure the distribution photodynamic drug in the brain to optimize dosage and treatment time (Conference Presentation)

Brandon Gaitan, Collin Inglut, Yu Chen, Huang-Chiao Huang

Proceedings Volume 11219, 112190J (2020) https://doi.org/10.1117/12.2550498

KEYWORDS: Luminescence, Brain, Optical tomography, Optical testing, Plasma display panels, Tissue optics, Tumors, Brain cancer, Blood brain barrier, Oxygen

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Proceedings Article | 26 February 2018 Presentation + Paper

Novel fiber optic-based needle redox imager for cancer diagnosis

Udayakumar Kanniyappan, He Xu, Qinggong Tang, Brandon Gaitan, Yi Liu, Lin Li, Yu Chen

Proceedings Volume 10489, 104890J (2018) https://doi.org/10.1117/12.2293133

KEYWORDS: Cancer, Endoscopy, Imaging systems, Breast cancer, Luminescence, Tissues, Fluorescence spectroscopy, Spectroscopy, In vivo imaging, In vitro testing

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Showing 5 of 9 publications

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