Dr. Chia-Pin Liang Profile

Dr. Chia-Pin Liang

Postdoctoral Research Fellow at Massachusetts General Hospital

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Publications (9)

Proceedings Article | 7 March 2019 Presentation

High-resolution micro-OCT for endothelial cell visualization in the coronary arteries (Conference Presentation)

Kensuke Nishimiya, Osman Ahsen, Biwei Yin, Zhonglie Piao, Jiheun Ryu, Hany Osman, Gargi Sharma, Hui Min Leung, Chia-Pin Liang, Joseph Gardecki, Guillermo Tearney

Proceedings Volume 10855, 1085502 (2019) https://doi.org/10.1117/12.2506264

KEYWORDS: Arteries, Visualization, Image segmentation, Scanning electron microscopy, Image resolution, Imaging technologies, Coherence (optics), Tomography, 3D image processing, Image processing

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Proceedings Article | 14 March 2018 Presentation

Optical coherence tomography-guided laser marking with tethered capsule endomicroscopy (Conference Presentation)

Chia-Pin Liang, Jing Dong, Timothy Ford, Rohith Reddy, Seyed Hamid Hosseiny Darbrazi, Hamid Farrokhi, Matthew Beatty, Kanwarpal Singh, Barry Vuong, Emilie Beaulieu-Ouellet, Catriona Grant, Sarah Giddings, Mireille Rosenberg, Norman Nishioka, Guillermo Tearney

Proceedings Volume 10470, 104700X (2018) https://doi.org/10.1117/12.2287843

KEYWORDS: Laser marking, Optical coherence tomography, Endomicroscopy, Endoscopy, Laser optics, Coherence (optics), Esophagus, Cancer, Surveillance, Diagnostics

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Proceedings Article | 19 April 2017 Presentation

A coaxially focused multi-mode beam for optical coherence tomography imaging with extended depth of focus (Conference Presentation)

Biwei Yin, Chia-Pin Liang, Barry Vuong, Guillermo Tearney

Proceedings Volume 10053, 100531N (2017) https://doi.org/10.1117/12.2254928

KEYWORDS: Coherence imaging, Optical imaging, Optical coherence tomography, Gaussian beams, Laser beam diagnostics, Fiber optics, Image resolution, Wavefronts, Confocal microscopy, Range imaging

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Proceedings Article | 19 April 2017 Presentation

Extended depth of focus tethered capsule OCT endomicroscopy for upper gastrointestinal tract imaging (Conference Presentation)

Barry Vuong, Biwei Yin, Emilie Beaulieu-Ouellet, Chia Pin Liang, Matthew Beatty, Kanwarpal Singh, Jing Dong, Catriona Grant, Mireille Rosenberg, Guillermo Tearney

Proceedings Volume 10040, 100400N (2017) https://doi.org/10.1117/12.2252103

KEYWORDS: Photomedicine, Optical coherence tomography, Endoscopy, Tissue optics, Endomicroscopy, Esophagus, Image resolution, Tissues, Imaging devices, Optomechanical components

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Endoscopy, the current standard of care for the diagnosis of upper gastrointestinal (GI) diseases, is not ideal as a screening tool because it is costly, necessitates a team of medically trained personnel, and typically requires that the patient be sedated. Endoscopy is also a superficial macroscopic imaging modality and therefore is unable to provide detailed information on subsurface microscopic structure that is required to render a precise tissue diagnosis. We have overcome these limitations through the development of an optical coherence tomography tethered capsule endomicroscopy (OCT-TCE) imaging device. The OCT-TCE device has a pill-like form factor with an optically clear wall to allow the contained opto-mechanical components to scan the OCT beam along the circumference of the esophagus. Once swallowed, the OCT-TCE device traverses the esophagus naturally via peristalsis and multiple cross-sectional OCT images are obtained at 30-40 μm lateral resolution by 7 μm axial resolution. While this spatial resolution enables differentiation of squamous vs columnar mucosa, crucial microstructural features such as goblet cells (~10 μm), which signify intestinal metaplasia in BE, and enlarged nuclei that are indicative of dysplasia cannot be resolved with the current OCT-TCE technology. In this work we demonstrate a novel design of a high lateral resolution OCT-TCE device with an extended depth of focus (EDOF). The EDOF is created by use of self-imaging wavefront division multiplexing that produces multiple focused modes at different depths into the sample. The overall size of the EDOF TCE is similar to that of the previous OCT-TCE device (~ 11 mm by 26 mm) but with a lateral resolution of ~ 8 μm over a depth range of ~ 2 mm. Preliminary esophageal and intestinal imaging using these EDOF optics demonstrates an improvement in the ability to resolve tissue morphology including individual glands and cells. These results suggest that the use of EDOF optics may be a promising avenue for increasing the accuracy of OCT-TCE for the diagnosis of upper GI diseases.

SPIE Journal Paper | 24 September 2014 Open Access

Real-time monitoring of hemodynamic changes in tumor vessels during photoimmunotherapy using optical coherence tomography

Chia-Pin Liang, Takahito Nakajima, Rira Watanabe, Kazuhide Sato, Peter Choyke, Yu Chen, Hisataka Kobayashi

JBO, Vol. 19, Issue 09, 098004, (September 2014) https://doi.org/10.1117/12.10.1117/1.JBO.19.9.098004

KEYWORDS: Tumors, Blood, Optical coherence tomography, Blood vessels, Photoimmunotherapy, Tissues, Hemodynamics, Near infrared, Cancer, In vivo imaging

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Proceedings Article | 22 May 2014 Paper

Quantitative analysis of low contrast detectability in optical coherence tomography

Nicholas Woolsey, Hsing-Wen Wang, Anant Agrawal, Jianting Wang, Chia-Pin Liang, Yu Chen, Joshua Pfefer

Proceedings Volume 9107, 91070C (2014) https://doi.org/10.1117/12.2053721

KEYWORDS: Optical coherence tomography, Scattering, Standards development, Tissues, Signal detection, Quantitative analysis, Medical imaging modalities, Signal attenuation, Visualization, Image resolution

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Proceedings Article | 10 March 2014 Paper

Quantitative assessment of biophotonic imaging system performance with phantoms fabricated by rapid prototyping

Jianting Wang, James Coburn, Nicholas Woolsey, Chia-Pin Liang, Jessica Ramella-Roman, Yu Chen, Joshua Pfefer

Proceedings Volume 8936, 89360M (2014) https://doi.org/10.1117/12.2044089

KEYWORDS: Printing, 3D printing, Optical coherence tomography, Imaging systems, Biomedical optics, Scattering, Reflectivity, Optical properties, Absorption, Rapid manufacturing

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Proceedings Article | 31 May 2013 Paper

Characterization and application of 3D-printed phantoms for biophotonic imaging

Jianting Wang, James Coburn, Chia-Pin Liang, Nicholas Woolsey, Du Le, Jessica Ramella-Roman, Yu Chen, Joshua Pfefer

Proceedings Volume 8719, 87190Y (2013) https://doi.org/10.1117/12.2018285

KEYWORDS: Absorption, Reflectivity, 3D printing, Biomedical optics, Printing, Optical coherence tomography, Tissues, Optical properties, Scattering, Hyperspectral imaging

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SPIE Journal Paper | 22 April 2013 Open Access

Concurrent multiscale imaging with magnetic resonance imaging and optical coherence tomography

Chia-Pin Liang, Bo Yang, Il Kyoon Kim, George Makris, Jaydev Desai, Rao Gullapalli, Yu Chen

JBO, Vol. 18, Issue 04, 046015, (April 2013) https://doi.org/10.1117/12.10.1117/1.JBO.18.4.046015

KEYWORDS: Optical coherence tomography, Magnetic resonance imaging, Tissues, Brain, Neuroimaging, Video, Thalamus, Signal attenuation, Breast, Imaging systems

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